The Seattle Hub for Synthetic Biology is researching and designing cutting-edge technologies that will monitor and record genomic changes in millions of cells simultaneously in real time to unveil their complete cellular histories and reveal the complete chain of events that cause healthy cells to progress into disease. Unlocking this insight has the potential to revolutionize how we diagnose and ultimately treat illnesses and will provide unprecedented clarity into how our environment shapes our fundamental biology.The work will be deployed at the scale of the whole organism and uncover how genetic or environmental changes give rise to specific characteristics in human cells and tissues, including those involved in disease. This team is also focused on developing technology that would not only diagnose disease, but also treat it.