According to the National Center for Biotechnology Information (NCBI), using the right gauge needle size is essential for administering the proper amount of medication in a safe and healthy way. As a result, needle gauge size (abbreviated as “G”) matters for both patient and the doctor. But deciphering the right needle gauge to use can be complicated. When it comes to identifying and purchasing the correct needle gauge sizes, there are several common questions that often pop up. Such as, “Is a 22G needle big or small?” or, “What’s a 22-gauge needle best used for?” Surprisingly there’s an inverse relationship between the gauge numbers and needle size. The needle gauge measures the needle diameter—the lower the gauge number, the wider the needle size will be. For example, An 18G needle will be wider than a 21G needle. A 22G needle is a smaller gauge needle size, making it perfect for use with healthy IV patients, who aren’t suffering from any dangerous illnesses.